This the necessity of breathing has forced into our knowledge. But how many other extrinsical and possibly very remote bodies do the springs of these admirable machines depend on, which are not vulgarly observed, or so much as thought on; and how many are there which the severest inquiry can never discover? The inhabitants of this spot of the universe, though removed so many millions of miles from the sun, yet depend so much on the duly tempered motion of particles coming from or agitated by it, that were this earth removed but a small part of the distance out of its present situation, and placed a little further or nearer that source of heat, it is more than probable that the greatest part of the animals in it would immediately perish: since we find them so often destroyed by an excess or defect of the sun's warmth, which an accidental position in some parts of this our little globe exposes them to. The qualities observed in a loadstone must needs have their source far beyond the confines of that body; and the ravage made often on several sorts of animals by invisible causes, the certain death (as we are told) of some of them, by barely passing the line, or, as it is certain of other, by being removed into a neighbouring country; evidently show that the concurrence and operations of several bodies, with which they are seldom thought to have anything to do, is absolutely necessary to make them be what they appear to us, and to preserve those qualities by which we know and distinguish them. We are then quite out of the way, when we think that things contain within themselves the qualities that appear to us in them; and we in vain search for that constitution within the body of a fly or an elephant, upon which depend those qualities and powers we observe in them. For which, perhaps, to understand them aright, we ought to look not only beyond this our earth and atmosphere, but even beyond the sun or remotest star our eyes have yet discovered. For how much the being and operation of particular substances in this our globe depends on causes utterly beyond our view, is impossible for us to determine. We see and perceive some of the motions and grosser operations of things here about us; but whence the streams come that keep all these curious machines in motion and repair, how conveyed and modified, is beyond our notice and apprehension: and the great parts and wheels, as Imay say so, of this stupendous structure of the universe, may, for aught we know, have such a connexion and dependence in their influences and operations one upon another, that perhaps things in this our mansion would put on quite another face, and cease to be what they are, if some one of the stars or great bodies incomprehensibly remote from us, should cease to be or move as it does. This is certain: things, however absolute and entire they seem in themselves, are but retainers to other parts of nature, for that which they are most taken notice of by us. Their observable qualities, actions, and powers are owing to something without them; and there is not so complete and perfect a part that we know of nature, which does not owe the being it has, and the excellences of it, to its neighbours; and we must not confine our thoughts within the surface of any body, but look a great deal further, to comprehend perfectly those qualities that are in it.
12. Our nominal essences of substances furnish few universal propositions about them that are certain. If this be so, it is not to be wondered that we have very imperfect ideas of substances, and that the real essences, on which depend their properties and operations, are unknown to us. We cannot discover so much as that size, figure, and texture of their minute and active parts, which is really in them; much less the different motions and impulses made in and upon them by bodies from without, upon which depends, and by which is formed the greatest and most remarkable part of those qualities we observe in them, and of which our complex ideas of them are made up. This consideration alone is enough to put an end to all our hopes of ever having the ideas of their real essences; which whilst we want, the nominal essences we make use of instead of them will be able to furnish us but very sparingly with any general knowledge, or universal propositions capable of real certainty.
13. Judgment of probability concerning substances may reach further: